Innate Immune DNA-Sensing Pathways
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چکیده
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell signaling pathogenic invasion. In response, innate immune DNA-sensing pathways launch an antimicrobial type I interferon (IFN) response, which becomes damaging to the host if unregulated or inappropriately activated by self-DNA. This Select highlights recent insights into activation and regulation of innate immune DNA-sensing pathways.
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ورودعنوان ژورنال:
- Cell
دوره 152 شماره
صفحات -
تاریخ انتشار 2013